N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺
更新时间：2021-02-05 17:20:10
采购接见：1次
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常用名 |
STF-62247 |
CAS号 |
315702-99-9 |
| 价钱 |
￥需询单/1g |
纯度 |
98.0% |
| 备货期 |
需询单 |
库存 |
询单 |
产物详情（用途，包装等）
用途：
STF-62247 is TGN inhibitor with IC50 of 0.625μM and 16μM in RCC4 and RCC4/VHL cells,respectively.It specifically induces autophagic cell death in cells that have lost VHL, an essential mutation in the development of RCC.IC50: 0.625/16μM in RCC4 and RCC4/VHL cells,respectively.[1]In vitro: STF-62247 induces cytotoxicity in VHL-deficient cells in a HIF-independent manner, STF-62247 increases acidification in VHL-deficient cells ,TGN is a target of STF-62247 and a drug-selective pathway synthetically lethal in VHL-deficient cells.[1] Golgi trafficking are required as initial signals in STF-62247-induced autophagy.[2]STF-62247 increases radiosensitivity in a VHL-dependent manner.[3]In vivo: SN12C, SN12C-VHL shRNA, or 786-O cells were implanted subcutaneously into the flanks of immunodeficient mice. The selective cytotoxicity of STF-62247 for the VHL-deficient cells was also demonstrated in 786-O cells compared to their wild-type VHL counterparts by clonogenic assay in vitro. Daily treatment with STF-62247 significantly reduced tumor growth of VHL-deficient cells. This decrease in tumor growth was concentration dependent. Importantly, drug treatment did not have any effect on the growth of SN12C tumor cells that have wild-type VHL. Together,STF-62247 reduces tumor growth in VHL-deficient cells in mice.[1]
物理化学性质：
CAS号：315702-99-9
常用中文名：STF-62247
常用英文名：STF-62247
分子式：C15H13N3S
分子量：267.349
密度：1.3±0.1 g/cm3
沸点：444.8±47.0 °C at 760 mmHg
熔点：N/A
闪点：222.8±29.3 °C
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