20(S)-原人参二醇
更新时间：2021-06-04 10:45:38
|
|
常用名 |
原人参二醇 |
CAS号 |
30636-90-9 |
| 价钱 |
￥需询单/20mg |
纯度 |
98.0% |
| 备货期 |
需询单 |
库存 |
现货 |
产物详情（用途，包装等）
用途：
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin; apoptosis inducer.IC50 value:Target: apoptosis inducer(20S)-Protopanaxadiol was used to induce cytotoxicity for two human glioma cell lines, SF188 and U87MG. For the SF188 cells, (20S)-Protopanaxadiol activated caspases-3, -8, -7, and -9 within 3 h and induced rapid apoptosis, which could be partially inhibited by a general caspase blocker and completely abolished when the caspase blocker was used in combination with an antioxidant. (20S)-Protopanaxadiol also induced cell death in U87MG cells but did not activate any caspases in these cells [1]. aPPD was able to inhibit P-gp activity as potently as verapamil on MDR cells. The blockage of P-gp activity was highly reversible as wash-out of aPPD resulted in an immediate recovery of P-gp activity. Unlike verapamil, aPPD did not affect ATPase activity of P-gp suggesting a different mechanism of action [2].
物理化学性子：
CAS号：30636-90-9
常用中文名：原人参二醇
常用英文名：(20S)-Protopanaxadiol
分子式：C30H52O3
分子量：460.732
密度：1.0±0.1 g/cm3
沸点：559.5±40.0 °C at 760 mmHg
熔点：N/A
闪点：226.1±21.9 °C
|
|
